Autoimmune vulgaris is a serious systemic dermatologic disease. It may affect the oral mucous membrane and skin. It is the most common subtype of pemphigus. 70% of all pemphigus cases worldwide. It is extremely rare in New Zealand. Women are more frequently affected than men and the disease is usually diagnosed between the ages of 50-70 years, often with oral blisters, but this medicine use for the first sign. Children are rarely affected. However, pemphigus tends to be more common in people of Middle Eastern or Jewish descent.
The exact cause of pemphigus is unknown, but it may be an autoimmune disorder. Sometimes pemphigus appears in reaction to medications, although this is rare. Pemphigus may be a side effect of certain blood pressure medications (ACE inhibitors) or chelating agents (medications, such as penicillamine, that remove certain materials from the blood).
Common symptoms are-
- Recurrent or relapsing in the body.
- Blistering, loose.
- Mouth or skin ulcers may can happen.
- Draining, oozing, crusting.
- Located on the mucous membrane of the mouth.
- Located on the scalp, trunk, or other skin areas.
- Spreading to other skin areas.
- Peeling superficially or detaching easily.
This disease is usually not responsive to treatment. The diagnosis of this type should prompt doctors to search for a hidden tumor. In some cases the tumor will be benign and the disease will improve if the tumor is surgically removed. When pemphigus vulgaris is known to be the diagnosis, the dermatology guideline is that a patient should be seen at a hospital by a Dermatology Consultant. However, it may become difficult to see a Dermatology Consultant in the first place to get a correct diagnosis and confirming tests.
At the present time, there are no cure only treatments to lessen the effects of the disease and allow some patients to lead more productive lives. Those treatments, many quite successful, center on the use of steroids such as prednisone and other corticosteroid medications. Chemotherapeutic immuno-suppressive drugs such as Imuran and Cytoxan are also administered to offset the disabling and toxic side effects of long-term prednisone use.
Differentiation from other oral and pharyngeal bullous diseases is easily made, because most of them produce subepithelial blisters, but small lesions may be mistaken for intraepithelial viral vesicles and any lesion may be confused with the oral keratinized blisters of Darier’s disease.